The only hospital located in Jackson County is the Northridge Medical Center in Commerce. Athens Regional and the Gwinnet Clinic have first care facilities located in Jefferson. Due to Jackson County's geographic location many citizens also go to medical facilities in Athens and Gainesville for services not provided locally.
- Northridge Medical Center: 706-335-1000 Website
- Athens Regional First Care of Jefferson: 706-387-5555 Website
- Northeast Georgia Physicians Group: 770-848-9315 Website
- The Gwinnett Clinic: 706-367-1894 Website